CN

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

Nickel, rod, 100mm, diameter 12.7mm, 99.98%

Cobalt, wire reel, 0.05m, diameter 0.25mm, hard, 99.99+%

Nickel, rod, 200mm, diameter 6.35mm, 99%

Nickel, foil, 10mm disks, thickness 0.30mm, as rolled, 99.98%

Nickel, rod, 200mm, diameter 20.0mm, 99%

Nickel, foil, 10mm disks, thickness 0.125mm, as rolled, 100%

Nickel, rod, 100mm, diameter 6.35mm, 99%

Cobalt, microfoil, disks, 10mm, thinness 0.5μm, specific density 434μg/cm², permanent mylar 3.5μm support, 99.9%

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Nickel, foil, thickness 0.1 mm, 99.98% trace metals basis

Sigma-Aldrich

Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

Nickel, foil, 8mm disks, thickness 0.03mm, 99.9%

Nickel, foil, light tested, 25x25mm, thickness 0.05mm, as rolled, 99.98%

Nickel, foil, 8mm disks, thickness 0.0075mm, 99.9%

Nickel, foil, light tested, 100x100mm, thickness 0.025mm, 99.9%

Cobalt, foil, 15mm disks, thickness 0.0125mm, 99.9%

Nickel, foil, 100x100mm, thickness 0.125mm, as rolled, 99.999%

Nickel, foil, 8mm disks, thickness 0.125mm, annealed, 99.98%

Cobalt, foil, 10mm disks, thickness 0.015mm, 99.9%

Cobalt, foil, 50x50mm, thickness 0.25mm, as rolled, 99.9%

Nickel, foil, 100x100mm, thickness 1.0mm, as rolled, 99.99+%

Nickel, foil, 25mm disks, thickness 0.25mm, annealed, 99.98%

Nickel, foil, 6mm disks, thickness 0.3mm, annealed, 99%