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Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: perspectives for biomedical applications.

Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: perspectives for biomedical applications.

The FEBS journal (2013-11-14)

Sonia Melino, Celeste Santone, Paolo Di Nardo, Bibudhendra Sarkar

ABSTRACT

Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability of histatins to inhibit collagenases and cysteine proteases, have attracted much attention for their potential use in the treatment of several oral diseases. This review critically assesses the studies carried out to date in order to provide a comprehensive and systematic vision of the information accumulated so far. In particular, the relationship between metal-binding and peptide activity is extensively analysed. The review provides important clues for developing possible therapeutic applications of histatins and their synthetic peptide analogues by creating a set of necessary resource materials to support investigators and industries interested in exploiting their unique properties.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Zinc, foil, thickness 1.0 mm, 99.99% trace metals basis

Sigma-Aldrich

Zinc, shot, 5 mm, 99.999% trace metals basis

Sigma-Aldrich

Copper, turnings, purum p.a., ≥99.0%

Sigma-Aldrich

Zinc, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.9%, granular

Sigma-Aldrich

Copper, foil, ≥99.8% (complexometric)

Sigma-Aldrich

Copper, foil, thickness 1.0 mm, 99.999% trace metals basis

Sigma-Aldrich

Copper, beads, 2-8 mm, 99.9995% trace metals basis

Sigma-Aldrich

Copper, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

Zinc, shot, <12 mm, 99.99% trace metals basis

Sigma-Aldrich

Copper, beads, 2-8 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Copper, wire, diam. 2.0 mm, 99.999% trace metals basis

Sigma-Aldrich

Copper, wire, diam. 0.64 mm, 99.995% trace metals basis

Sigma-Aldrich

Copper, foil, thickness 0.5 mm, 99.98% trace metals basis

Sigma-Aldrich

Copper, wire, diam. 1.0 mm, ≥99.9%

Sigma-Aldrich

Copper, wire, diam. 0.25 mm, 99.999% trace metals basis

Copper, wire reel, 500m, diameter 0.05mm, annealed, 99.9%

Zinc, foil, 10mm disks, thickness 0.025mm, as rolled, 99.95+%

Zinc, foil, 0.5m coil, thickness 0.05mm, as rolled, 99.95+%

Copper, wire reel, 0.5m, diameter 0.125mm, as drawn, 99.99+%

Copper - O.F.H.C., foil, 50mm disks, thickness 0.010mm, hard, 99.95+%

Copper, wire reel, 1000m, diameter 0.075mm, annealed, 99.9%

Zinc, foil, 25x25mm, thickness 3mm, as rolled, 99.99+%

Copper, tube, 500mm, outside diameter 5.0mm, inside diameter 4mm, wall thickness 0.5mm, as drawn, 99.9%

Copper, wire reel, 2000m, diameter 0.075mm, annealed, 99.9%

Zinc, foil, 15mm disks, thickness 0.05mm, as rolled, 99.99+%

Copper - O.F.H.C., foil, 5m coil, thickness 0.1mm, coil width 100mm, hard, 99.95+%

Zinc, foil, 10mm disks, thickness 0.15mm, as rolled, 99.95+%

Copper - O.F.H.C., foil, 4mm disks, thickness 0.025mm, hard, 99.95+%

Zinc, foil, 10mm disks, thickness 0.25mm, as rolled, 99.99+%

Zinc, foil, 25x25mm, thickness 6mm, as rolled, 99.99+%