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Nickel trafficking system responsible for urease maturation in Helicobacter pylori.

Nickel trafficking system responsible for urease maturation in Helicobacter pylori.

World journal of gastroenterology (2013-12-24)

Rui-Guang Ge, Dong-Xian Wang, Ming-Cong Hao, Xue-Song Sun

ABSTRACT

Helicobacter pylori (H. pylori) is a common human pathogen responsible for various gastric diseases. This bacterium relies on the production of urease and hydrogenase to inhabit the acidic environment of the stomach. Nickel is an essential cofactor for urease and hydrogenase. H. pylori has to uptake sufficient nickel ions for the maturation of urease, and on the other way, to prevent the toxic effects of excessive nickel ions. Therefore, H. pylori has to strike a delicate balance between the import of nickel ions, its efficient intracellular storage, and delivery to nickel-dependent metalloenzymes when required. The assembly and maturation of the urease enzyme is a complex and timely ordered process, requiring various regulatory, uptake, chaperone and accessory proteins. In this review, we focus on several nickel trafficking proteins involved in urease maturation: NikR, NixA, HypAB, UreEFGH, HspA, Hpn and Hpnl. The work will deepen our understanding of how this pathogenic bacterium adapts to severe habitant environments in the host.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Nickel, foil, thickness 0.5 mm, 99.98% trace metals basis

Sigma-Aldrich

Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

Sigma-Aldrich

Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

Sigma-Aldrich

Nickel, foil, thickness 0.1 mm, 99.98% trace metals basis

Sigma-Aldrich

Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

Nickel, foil, light tested, 100x100mm, thickness 0.007mm, 99.95%

Nickel, foil, not light tested, 25x25mm, thickness 0.0005mm, temporary acrylic support, 99.95%

Nickel, wire reel, 10m, diameter 0.125mm, annealed, 99.98%

Nickel, wire reel, 0.2m, diameter 0.5mm, as drawn, 99.99+%

Nickel, tube, 500mm, outside diameter 2.8mm, inside diameter 1.8mm, wall thickness 0.5mm, hard, 99.5%

Nickel, foil, 10mm disks, thickness 0.03mm, 99.9%

Nickel, foil, 0.2m coil, thickness 0.005mm, as rolled, 99.9%

Nickel, tube, 500mm, outside diameter 8.4mm, inside diameter 8.15mm, wall thickness 0.125mm, hard, 99.5%

Nickel, foil, 2m coil, thickness 0.075mm, as rolled, 99.98%

Nickel, foil, 0.5m coil, thickness 0.0125mm, annealed, 99%

Nickel, wire reel, 0.5m, diameter 0.05mm, as drawn, 99.99+%

Nickel, foil, 2m coil, thickness 0.25mm, annealed, 99.98%

Nickel, foil, 0.5m coil, thickness 0.15mm, annealed, 99%

Nickel, wire reel, 100m, diameter 0.5mm, as drawn, 99%

Nickel, wire reel, 5m, diameter 0.025mm, as drawn, 99.98%

Nickel, wire reel, 50m, diameter 0.125mm, hard, 99.98%

Nickel, wire reel, 50m, diameter 0.25mm, hard, 99.98%

Nickel, foil, 25mm disks, thickness 0.125mm, as rolled, 99.99+%

Nickel, tube, 200mm, outside diameter 5.9mm, inside diameter 5.65mm, wall thickness 0.125mm, hard, 99.5%

Nickel, wire reel, 50m, diameter 0.5mm, as drawn, 99%

Nickel, wire reel, 250m, diameter 0.25mm, annealed, 99%

Nickel, wire reel, 500m, diameter 0.125mm, hard, 99.98%

Nickel, foil, 6mm disks, thickness 0.0125mm, 99.9%

Nickel, foil, 6mm disks, thickness 0.038mm, 99.9%

Nickel, wire reel, 500m, diameter 0.15mm, as drawn, 99%