Pharmacokinetics of the new progestogens and influence of gestodene and desogestrel on ethinylestradiol metabolism.

Pharmacokinetics of the new progestogens and influence of gestodene and desogestrel on ethinylestradiol metabolism.

Contraception (1997-05-01)

F Z Stanczyk

PMID9220223

ABSTRACT

The purpose of the present report is to summarize the most important pharmacokinetic features of the new progestogens. In addition, the question of whether or not gestodene, in comparison to desogestrel, has an influence on the pharmacokinetics of ethinylestradiol (EE2) will be addressed.

MATERIALS

Product Number

Brand

Product Description

Y0001112

Gestodene, European Pharmacopoeia (EP) Reference Standard

E-076

Supelco

17α-Ethynylestradiol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

E4876

Sigma-Aldrich

17α-Ethynylestradiol, ≥98%