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  • Preservatives in cosmetics in the Israeli market conform well to the EU legislation.

Preservatives in cosmetics in the Israeli market conform well to the EU legislation.

Journal of the European Academy of Dermatology and Venereology : JEADV (2014-09-02)
L Horev, M Isaksson, M Engfeldt, L Persson, A Ingber, M Bruze
ABSTRACT

Preservatives are important and frequent skin sensitizers, found in a wide range of products for personal and occupational use. According to the European legislation, some cosmetic ingredients are restricted in terms of quantity and a detailed list of ingredients must be present on the product or packaging. To examine the use of preservatives in common cosmetics on the Israeli market. Sixty different Israeli brand cosmetics, including shampoos, liquid soaps, body creams and hand creams were randomly selected. Ingredient labels were examined. The products were investigated by the chromotropic acid method for release of formaldehyde and by high performance liquid chromatography for the presence of formaldehyde, DMDM hydantoin and methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI content. All products but one contained a detailed list of ingredients printed on the package. According to labelling, the most prevalent preservatives in Israeli shampoos and liquid soaps were DMDM hydantoin and MCI/MI. Hand creams and body creams contained mainly parabens but also iodopropynyl butylcarbamate, phenoxyethanol and DMDM hydantoin. Formaldehyde in doses from 4 to 429 ppm, and DMDM hydantoin were detected in 38 and 16 (63% and 27%) of the products, respectively. MCI/MI was detected in 11 (18%) of the products, with highest prevalence in rinse- off products (55%). Excluding one hand cream which measured 106 ppm MI, the amount of formaldehyde, DMDM hydantoin, MCI/MI and MI was within the allowed concentrations by the European directive in all cases. In Israel, adaptation of the European directive prevails, as shown by the measurements we performed on randomly selected products.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Methanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)
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Sodium chloride, Vetec, reagent grade, 99%
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Sodium hydroxide, anhydrous, free-flowing, Redi-Dri, reagent grade, ≥98%, pellets
Supelco
Formaldehyde solution, stabilized with methanol, ~37 wt. % in H2O, certified reference material
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Ammonium acetate solution, Molecular Biology, 7.5 M
SAFC
Sodium chloride solution, 5 M
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Sodium hydroxide, puriss., meets analytical specification of Ph. Eur., BP, NF, E524, 98-100.5%, pellets
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Diethyl ether, puriss., contains ~5 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer, meets analytical specification of Ph. Eur., BP, ≥99.5% (GC)
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Methanol, suitable for HPLC, gradient grade, suitable as ACS-grade LC reagent, ≥99.9%
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Tetrahydrofuran, contains 250 ppm BHT as inhibitor, puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.9%
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Sodium hydroxide, puriss. p.a., ACS reagent, reag. Ph. Eur., K ≤0.02%, ≥98%, pellets
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Phosphoric acid solution, 85 wt. % in H2O, FCC, FG
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Methanol, purification grade, 99.8%
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Tetrahydrofuran, inhibitor-free, purification grade
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Phosphoric acid solution, suitable for NMR (reference standard), 85% in D2O (99.9 atom % D), NMR tube size 3 mm × 8 in.
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Phosphoric acid solution, suitable for NMR (reference standard), 85% in D2O (99.9 atom % D), NMR tube size 5 mm × 8 in.
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Sodium hydroxide, ultra dry, powder or crystals, 99.99% trace metals basis
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Ammonium acetate, Vetec, reagent grade, 97%
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Sodium chloride-35Cl, 99 atom % 35Cl
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Acetic acid, natural, ≥99.5%, FG
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Sodium chloride, random crystals, 99.9% trace metals basis
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Formaldehyde-12C solution, 20% in H2O, 99.9 atom % 12C
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Acetic acid-12C2, 99.9 atom % 12C
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Phosphoric acid solution, suitable for NMR (reference standard), 85% in D2O (99.9 atom % D), NMR tube size 4.2 mm × 8 in. , WGS-5BL Coaxial NMR tube
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3-Ethyl-2,4-pentanedione, mixture of tautomers, 98%
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Formaldehyde solution, tested according to Ph. Eur.
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Formaldehyde solution, Molecular Biology, BioReagent, ≥36.0% in H2O (T)
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Formaldehyde solution, ACS reagent, 37 wt. % in H2O, contains 10-15% Methanol as stabilizer (to prevent polymerization)
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Formaldehyde solution, Molecular Biology, 36.5-38% in H2O
SAFC
Formaldehyde solution, contains 10-15% methanol as stabilizer, 37 wt. % in H2O