- Monitoring neonatal fungal infection with metabolomics.
Monitoring neonatal fungal infection with metabolomics.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2014-10-07)
Angelica Dessì, Barbara Liori, Pierluigi Caboni, Giovanni Corsello, Mario Giuffrè, Antonio Noto, Francesca Serraino, Mauro Stronati, Marco Zaffanello, Vassilios Fanos
PMID25284175
ABSTRACT
The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.
MATERIALS
Product Number
Brand
Product Description
Supelco
D-(−)-Fructose, analytical standard, analytical standard for fructose assay kit, for use with enzymatic assay kit FA20
Sigma-Aldrich
D-(−)-Fructose, ≥99% (HPLC), BioReagent, suitable for cell culture, suitable for insect cell culture
Palmitic acid, European Pharmacopoeia (EP) Reference Standard
L-Threonine, European Pharmacopoeia (EP) Reference Standard
Fructose, European Pharmacopoeia (EP) Reference Standard
Supelco
Chlorotrimethylsilane, derivatization grade (GC derivatization), LiChropur™, ≥99.0% (GC)