- Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.
Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.
Bulletin of experimental biology and medicine (2015-06-03)
G N Zyuz'kov, V V Zhdanov, L A Miroshnichenko, E V Udut, A V Chaikovskii, E V Simanina, M G Danilets, M Yu Minakova, V V Udut, T G Tolstikova, E E Shults, L A Stavrova, Ya V Burmina, A M Dygai
PMID26033591
ABSTRACT
We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation.
MATERIALS
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Product Description
Sigma-Aldrich
L-Glutamine, meets USP testing specifications, suitable for cell culture, 99.0-101.0%, from non-animal source