Is GIGYF2 the defective gene at the PARK11 locus?

The number of genes and loci for Parkinson's disease was expanded during 2008. Among the most interesting findings of the year was the nomination of GIGYF2 as the gene that is defective at the PARK11 locus and is a potentially frequent cause of typical Parkinson's disease. However, the optimism generated by the initial report has quickly been tempered by results obtained in the first wave of follow-up studies.