- Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.
Biochimica et biophysica acta (2016-11-16)
Marina Sokolova, Leif Erik Vinge, Katrine Alfsnes, Maria Belland Olsen, Lars Eide, Ole Jørgen Kaasbøll, Håvard Attramadal, May-Kristin Torp, Linn E Fosshaug, Azita Rashidi, Egil Lien, Alexandra Vanessa Finsen, Øystein Sandanger, Pål Aukrust, Trine Ranheim, Arne Yndestad
PMID27845246
ABSTRACT
Palmitate triggers inflammatory responses in several cell types, but its effects on cardiac fibroblasts are at present unknown. The aims of the study were to (1) assess the potential of palmitate to promote inflammatory signaling in cardiac fibroblasts through TLR4 and the NLRP3 inflammasome and (2) characterize the cellular phenotype of cardiac fibroblasts exposed to palmitate. We examined whether palmitate induces inflammatory responses in cardiac fibroblasts from WT, NLRP3