- Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.
Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.
Molecular carcinogenesis (2016-11-02)
Nancy Lévesque, Karen E Christensen, Lauren Van Der Kraak, Ana F Best, Liyuan Deng, Don Caldwell, Amanda J MacFarlane, Nicole Beauchemin, Rima Rozen
PMID27597531
ABSTRACT
The common R653Q variant (∼20% homozygosity in Caucasians) in the synthetase domain of the folate-metabolizing enzyme MTHFD1 reduces purine synthesis. Although this variant does not appear to affect risk for colorectal cancer, we questioned whether it would affect growth of colorectal tumors. We induced tumor formation in a mouse model for MTHFD1-synthetase deficiency (Mthfd1S