- Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts.
Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017-02-01)
Julia Straubinger, Karsten Boldt, Anna Kuret, Lisa Deng, Diana Krattenmacher, Nadja Bork, Matthias Desch, Robert Feil, Susanne Feil, Mona Nemer, Marius Ueffing, Peter Ruth, Steffen Just, Robert Lukowski
PMID28138039
ABSTRACT
LIM domain proteins have been identified as essential modulators of cardiac biology and pathology; however, it is unclear which role the cysteine-rich LIM-only protein (CRP)4 plays in these processes. In studying CRP4 mutant mice, we found that their hearts developed normally, but lack of CRP4 exaggerated multiple parameters of the cardiac stress response to the neurohormone angiotensin II (Ang II). Aiming to dissect the molecular details, we found a link between CRP4 and the cardioprotective cGMP pathway, as well as a multiprotein complex comprising well-known hypertrophy-associated factors.