- STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.
STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.
The EMBO journal (2017-04-06)
Léa P Wilhelm, Corinne Wendling, Benoît Védie, Toshihide Kobayashi, Marie-Pierre Chenard, Catherine Tomasetto, Guillaume Drin, Fabien Alpy
PMID28377464
ABSTRACT
StAR-related lipid transfer domain-3 (STARD3) is a sterol-binding protein that creates endoplasmic reticulum (ER)-endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the intracellular distribution of this lipid was ill-defined. Here, by using
MATERIALS
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Brand
Product Description
Sigma-Aldrich
U18666A, A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.