- The potential of Epimedium koreanum Nakai for herb-drug interaction.
The potential of Epimedium koreanum Nakai for herb-drug interaction.
The Journal of pharmacy and pharmacology (2017-06-28)
Qingxiang Zhong, Ziqi Shi, Li Zhang, Rongling Zhong, Zhi Xia, Jing Wang, Hao Wu, Yutong Jiang, E Sun, Yingjie Wei, Liang Feng, Zhenhai Zhang, Dan Liu, Jie Song, Xiaobin Jia
PMID28653752
ABSTRACT
This study aims to investigate potential herb-drug interactions (HDI) of Epimedium koreanum Nakai. Human liver microsomes (HLMs) were used to determine the enzyme kinetics of the major human cytochrome P450s (CYPs). Inducible potential of E. koreanum on CYP1A2, 2B6, 2C19 and 3A4 activities of human primary hepatocytes was also examined. Ethanol extract of E. koreanum showed direct inhibitory potency for CYP1A2 (IC The ethanol extract of E. koreanum is not likely to cause HDI via inducing the major human CYPs. But the potential for interactions between E. koreanum extract and substrates of CYP1A2 or 2B6 cannot be overlooked.
MATERIALS