- Twin birth changes DNA methylation of subsequent siblings.
Twin birth changes DNA methylation of subsequent siblings.
Scientific reports (2017-08-18)
Shuai Li, Eunae Kim, Ee Ming Wong, Ji-Hoon Eric Joo, Tuong L Nguyen, Jennifer Stone, Yun-Mi Song, Louisa B Flander, Richard Saffery, Graham G Giles, Melissa C Southey, Joohon Sung, John L Hopper
PMID28814741
ABSTRACT
We asked if twin birth influences the DNA methylation of subsequent siblings. We measured whole blood methylation using the HumanMethylation450 array for siblings from two twin and family studies in Australia and Korea. We compared the means and correlations in methylation between pairs of siblings born before a twin birth (BT siblings), born on either side of a twin birth (B/AT pairs) and born after a twin birth (AT siblings). For the genome-wide average DNA methylation, the correlation for AT pairs (r
MATERIALS