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  • Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells.

Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells.

Oncotarget (2017-09-09)
Yong-Hao Huang, Yan Sun, Feng-Ying Huang, Yue-Nan Li, Cai-Chun Wang, Wen-Li Mei, Hao-Fu Dai, Guang-Hong Tan, Canhua Huang
ABSTRACT

Colorectal cancer is the most common cancer. It has high morbidity and mortality worldwide, and more effective treatment strategies need to be developed. Toxicarioside O (TCO), a natural product derived from

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
3-Methyladenine, autophagy inhibitor
Sigma-Aldrich
Anti-LC3B antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Sigma-Aldrich
EX-527, ≥98% (HPLC)