- Rapid analysis of benzalkonium chloride using paper spray mass spectrometry.
Rapid analysis of benzalkonium chloride using paper spray mass spectrometry.
Journal of pharmaceutical and biomedical analysis (2017-07-01)
Jingjing Liu, Wenjie Deng, Muqian Yu, Ruizhi Wen, Shouzhuo Yao, Bo Chen
PMID28666161
ABSTRACT
A paper spray mass spectrometry (PS-MS) method for rapid and reliable analysis of benzalkonium chloride (BAC) in compound eye drops and body surface disinfectant was developed. The sample was dropped onto triangular filter paper, and high voltage (3.5kV) was applied to form an electrospray. This method can provide the composition of benzalkonium chloride in samples without pretreatment, solvent or chromatographic separation, and the analysis time is only 10s. The primary homologues C
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