- The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans.
The role of charge in the toxicity of polymer-coated cerium oxide nanomaterials to Caenorhabditis elegans.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP (2017-09-11)
Devrah A Arndt, Emily K Oostveen, Judy Triplett, D Allan Butterfield, Olga V Tsyusko, Blanche Collin, Daniel L Starnes, Jian Cai, Jon B Klein, Richard Nass, Jason M Unrine
PMID28888877
ABSTRACT
This study examined the impact of surface functionalization and charge on ceria nanomaterial toxicity to Caenorhabditis elegans. The examined endpoints included mortality, reproduction, protein expression, and protein oxidation profiles. Caenorhabditis elegans were exposed to identical 2-5nm ceria nanomaterial cores which were coated with cationic (diethylaminoethyl dextran; DEAE), anionic (carboxymethyl dextran; CM), and non-ionic (dextran; DEX) polymers. Mortality and reproductive toxicity of DEAE-CeO