- Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy.
Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy.
Molecular cancer therapeutics (2017-07-19)
Roberto De Luca, Alex Soltermann, Francesca Pretto, Catherine Pemberton-Ross, Giovanni Pellegrini, Sarah Wulhfard, Dario Neri
PMID28716814
ABSTRACT
A novel biopharmaceutical, consisting of the F8 mAb (specific to a splice isoform of fibronectin) simultaneously fused to both TNF and IL2, was found to react with the majority of solid tumors and hematologic malignancies in mouse and man, but not with healthy adult tissues. The product selectively localized to neoplastic lesions
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Anti-Caspase 3, Active antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution