Serotonin 2B Receptors in Mesoaccumbens Dopamine Pathway Regulate Cocaine Responses.

Serotonin 2B Receptors in Mesoaccumbens Dopamine Pathway Regulate Cocaine Responses.

The Journal of neuroscience : the official journal of the Society for Neuroscience (2017-09-25)

Stéphane Doly, Emily Quentin, Raphaël Eddine, Stefania Tolu, Sebastian P Fernandez, Jesus Bertran-Gonzalez, Emmanuel Valjent, Arnauld Belmer, Xavier Viñals, Jacques Callebert, Philippe Faure, Frank J Meye, Denis Hervé, Patricia Robledo, Manuel Mameli, Jean-Marie Launay, Rafael Maldonado, Luc Maroteaux

PMID28935766

ABSTRACT

Addiction is a maladaptive pattern of behavior following repeated use of reinforcing drugs in predisposed individuals, leading to lifelong changes. Common among these changes are alterations of neurons releasing dopamine in the ventral and dorsal territories of the striatum. The serotonin 5-HT