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Merck
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Metabolomic effects of CeO

Particle and fibre toxicology (2017-12-01)
Kirk T Kitchin, Steve Stirdivant, Brian L Robinette, Benjamin T Castellon, Xinhua Liang
ABSTRACT

To better assess potential hepatotoxicity of nanomaterials, human liver HepG2 cells were exposed for 3 days to five different CeO Four CeO Metal oxide nanomaterial exposure may compromise the methylation, glucuronidation and reduced glutathione conjugation systems; thus Phase II conjugational capacity of hepatocytes may be decreased. This metabolomics study of the effects of nine different nanomaterials has not only confirmed some observations of the prior 2014 study (lipid elevations caused by one CeO