CN
- Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study.
Silicon containing ibuprofen derivatives with antioxidant and anti-inflammatory activities: An in vivo and in silico study.
European journal of pharmacology (2017-08-02)
David J Pérez, M Irene Díaz-Reval, Fernando Obledo-Benicio, Uzma I Zakai, Zeferino Gómez-Sandoval, Rodrigo Said Razo-Hernández, Robert West, María Teresa Sumaya-Martínez, Kayim Pineda-Urbina, Ángel Ramos-Organillo
PMID28757324
ABSTRACT
There are many chronic diseases related with inflammation. The chronic inflammation can produce other problems as cancer. Therefore, it is necessary to design drugs with better anti-inflammatory activity than those in the clinic. Likewise, these could be used in chronic treatments with minimum adverse effects. The amide or ester functionality in combination with the insertion of a silyl alkyl moiety is able to improve some drug properties. In this context, the evaluation of a group of silicon containing ibuprofen derivatives (SCIDs) as antioxidants and anti-inflammatory agents is reported. Antioxidant activity was evaluated by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH⨪), 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic) acid (ABTS
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