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  • IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis.

IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017-08-20)
Ellyse Cipolla, Amanda J Fisher, Hongmei Gu, Elizabeth A Mickler, Manisha Agarwal, Carol A Wilke, Kevin K Kim, Bethany B Moore, Ragini Vittal
PMID28821630
ABSTRACT

Interleukin 17A (IL-17A) and complement (C') activation have each been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We have reported that IL-17A induces epithelial injury