- Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in
Conserved forkhead dimerization motif controls DNA replication timing and spatial organization of chromosomes in
Proceedings of the National Academy of Sciences of the United States of America (2017-03-08)
A Zachary Ostrow, Reza Kalhor, Yan Gan, Sandra K Villwock, Christian Linke, Matteo Barberis, Lin Chen, Oscar M Aparicio
PMID28265091
ABSTRACT
Forkhead Box (Fox) proteins share the Forkhead domain, a winged-helix DNA binding module, which is conserved among eukaryotes from yeast to humans. These sequence-specific DNA binding proteins have been primarily characterized as transcription factors regulating diverse cellular processes from cell cycle control to developmental fate, deregulation of which contributes to developmental defects, cancer, and aging. We recently identified