- Selective metalation of 6-methylpurines: synthesis of 6-fluoromethylpurines and related nucleosides.
Selective metalation of 6-methylpurines: synthesis of 6-fluoromethylpurines and related nucleosides.
Nucleosides, nucleotides & nucleic acids (2003-10-21)
Abdalla E A Hassan, William B Parker, Paula W Allan, John A Montgomery, John A Secrist
PMID14565269
ABSTRACT
A selective metalation at the 6-CH3 over C-8 of 6-methylpurine derivative 6 was observed with softer counter cation (Na+ or K+) of the base, while the harder Li+ showed no selectivity. In the presence of N-fluorobenzenesulfonamide (NFSI), this property was utilized for the synthesis of 6-fluoromethylpurine derivatives 4 and 5 as potential toxins for suicide gene therapy.
MATERIALS
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Product Description
Supelco
Discovery® C8 Supelguard Guard Cartridge Kit, 5 μm particle size, L × I.D. 2 cm × 4 mm, contains 2 nuts, 2 ferrules, 5cm tubing, 1 guard cartridge and 1 guard holder