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  • CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease.

CD45 exon 4 point mutation does not confer susceptibility to type 1 diabetes mellitus or Graves' disease.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics (2002-02-14)
J P Wood, K Bieda, M Segni, J Herwig, M Krause, K H Usadel, K Badenhoop
PMID11841494
ABSTRACT

A point mutation in the leukocyte common antigen (CD45, C-->G77, exon 4) was investigated in patients with type 1 diabetes (IDDM), patients with Graves' disease and controls. The distribution did not differ significantly between patients and controls. This CD45 variant does not therefore confer susceptibility to either IDDM or Graves' disease.