Most pharmaceuticals and cosmetic actives currently on the market are delivered transdermally or topically via a passive diffusion route. Strat-M® membranes were developed to mimic this passive diffusion process. This synthetic membrane was designed to provide a non-animal model for transdermal diffusion and safety testing of cosmetic actives, formulations, personal care products, active pharmaceutical ingredients (API), and pesticides and chemicals. We developed a protocol for diffusion testing of caffeine formulations using Strat-M® membranes. This protocol can be used as a basis for diffusion testing of other compounds using Strat-M® membranes.
Caffeine Solution in Propylene Glycol + Oleic Acid
Receptor Solution (Phosphate Buffered Saline, pH 7.4)
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