149837
2-乙氧基-1-乙氧羰基-1,2-二氢喹啉
≥99%, for peptide synthesis
别名:
2-乙氧基-1,2-二氢-1-喹啉羧酸乙酯, N-乙氧羰基-2-乙氧基-1,2-二氢喹啉, EEDQ
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关于此项目
经验公式（希尔记法）:
C14H17NO3
化学文摘社编号:
分子量:
247.29
Beilstein:
533048
EC 号:
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
产品名称
2-乙氧基-1-乙氧羰基-1,2-二氢喹啉, ≥99%
质量水平
方案
≥99%
表单
solid
反应适用性
reaction type: Coupling Reactions
mp
62-67 °C (lit.)
应用
peptide synthesis
官能团
ether
储存温度
2-8°C
SMILES字符串
CCOC1C=Cc2ccccc2N1C(=O)OCC
InChI
1S/C14H17NO3/c1-3-17-13-10-9-11-7-5-6-8-12(11)15(13)14(16)18-4-2/h5-10,13H,3-4H2,1-2H3
InChI key
GKQLYSROISKDLL-UHFFFAOYSA-N
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一般描述
2-乙氧基-1-乙氧羰基-1,2-二氢喹啉(EEDQ)是稳定试剂，可用于高产率制备酰胺和多肽。本品提供现成货品。室温下，可溶于含有机溶剂的水性介质，但不溶于水。 用作肽合成偶联剂。
应用
2-乙氧基-1-乙氧羰基-1,2-二氢喹啉用作偶联剂：
- 用于壳聚糖及其两亲性衍生物的区域选择性季铵化。
- 用于制备酰胺型S-MA（扁桃酸）衍生物修饰的石英晶体微天平(QCM)传感器。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
S Kapur et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 23(5), 595-598 (2000-10-12)
Two techniques are commonly used to measure antipsychotic induced dopamine D(2) occupancy in animals: competition with a reversible radioligand (3H-raclopride) or with an irreversible receptor inactivator (EEDQ). While both of these techniques have been used in the past, there is
Toshiaki Miki et al.
Journal of biochemistry, 141(3), 377-387 (2007-01-20)
Chemical modification of the bovine heart cytochrome bc1 complex with N-(ethoxycarbonyl)-2-ethoxy-1,2-dihydroquinoline (EEDQ) has been reported to inhibit the proton pumping activity without affecting the rate of electron transfer to ferricytochrome c. This study aims to examine the effect of EEDQ
Development of real-time sensitive chiral analysis technique using quartz crystal analyzer
Kim JM, et al.
Sensors and Actuators B, Chemical, 171, 478-485 (2012)
Didier Cussac et al.
Molecular pharmacology, 62(3), 578-589 (2002-08-16)
As determined by a guanosine 5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS) binding assay, which does not distinguish G protein subtypes, 5-hydroxytryptamine (5-HT) and 2(S)- 1-(6-chloro-5-fluoro-1H-indol-1-yl)-2-propanamine fumarate (Ro600175) behaved as full agonists at human 5-HT(2C) (h5-HT(2C)) receptors (VSV isoform) stably expressed in Chinese hamster ovary
H Gozlan et al.
Neuropharmacology, 33(3-4), 423-431 (1994-03-01)
The effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), an alkylating agent producing irreversible blockade of various membrane bound receptors in brain, were investigated on four different types of serotonin receptors, 5-HT1A, 5-HT1B, 5-HT2A and 5-HT3, in various brain regions in the rat. In
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