160210
氯甲酸对硝基苯酯
96%, for peptide synthesis
别名:
氯甲酸-4-硝基苯酯
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关于此项目
线性分子式:
ClCO2C6H4NO2
化学文摘社编号:
分子量:
201.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352108
EC Number:
231-706-9
MDL number:
Beilstein/REAXYS Number:
518127
产品名称
氯甲酸对硝基苯酯, 96%
form
powder
InChI key
NXLNNXIXOYSCMB-UHFFFAOYSA-N
InChI
1S/C7H4ClNO4/c8-7(10)13-6-3-1-5(2-4-6)9(11)12/h1-4H
SMILES string
[O-][N+](=O)c1ccc(OC(Cl)=O)cc1
assay
96%
reaction suitability
reaction type: Carbonylations
bp
159-162 °C/19 mmHg (lit.)
mp
77-79 °C (lit.)
application(s)
peptide synthesis
storage temp.
2-8°C
Quality Level
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Application
4-硝基苯基氯甲酸酯用于：
- 作为偶联剂连接药物分子与聚轮烷载体
- 作为活化酯试剂，使多肽共价偶联大分子单体，例如(聚(乙二醇)延胡索酸酯)低聚物(OPF)
General description
4-硝基苯基氯甲酸酯，也称为氯甲酸对硝基苯酯，可作为偶联剂合成尿素、甲酸酯和碳酸酯。也用作固相肽合成(SPPS)构件，用于获得不同的侧链官能团。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Zhuojun Gu et al.
Drug development and industrial pharmacy, 41(5), 812-818 (2014-04-22)
Polyamidoamine (PAMAM) dendrimers have attracted lots of interest as drug carriers. And little study about whether pluronic-attached PAMAM dendrimers could be potential drug delivery systems has been carried on. Pluronic F127 (PF127) attached PAMAM dendrimers were designed as novel drug
Synthesis and characterization of poly (oxyethylene) modified dextrans
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Macromolecular Rapid Communications, 15(9), 697-697 (1994)
Modification of oligo (poly (ethylene glycol) fumarate) macromer with a GRGD peptide for the preparation of functionalized polymer networks
S Jo, et al.
Biomacromolecules, 2, 255-261 (2001)
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