21860
1,1′-羰基二咪唑
≥97.0% (T), for peptide synthesis
别名:
CDI
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关于此项目
经验公式（希尔记法）:
C7H6N4O
化学文摘社编号:
分子量:
162.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352115
EC Number:
208-488-9
MDL number:
Beilstein/REAXYS Number:
6826
产品名称
1,1′-羰基二咪唑, ≥97.0% (T)
InChI key
PFKFTWBEEFSNDU-UHFFFAOYSA-N
InChI
1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
SMILES string
O=C(n1ccnc1)n2ccnc2
assay
≥97.0% (T)
form
solid
reaction suitability
reaction type: Carbonylations
greener alternative product characteristics
Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
115-122 °C, 117-122 °C (lit.)
application(s)
peptide synthesis
greener alternative category
storage temp.
2-8°C
Quality Level
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General description
CDI作为一种功能强大的偶联试剂用于多肽合成和有机化学。
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. 1,1′-carbonyldiimidazole (CDI) is an alternative to highly toxic insidious poison phosgene and thus aligns with the principle "Designing Safer Chemicals". Click here for more information.
Application
使用CDI（1,1′-羰基咪唑）：
- 用于活化丙二酸衍生物，以通过轻微脱羧制备羰基咪唑
- 用于活化纤维素膜，以开发免疫传感器。
- 用于合成替代1,3-恶唑[4,5-d]哒嗪酮。
- 作为各种异羟肟酸通过洛森重排转化为异氰酸酯的试剂。
- 用于合成1,3,4-恶二唑衍生物及水中的多肽硫酯。
- 作为酰化剂合成氨基甲酸盐。
Other Notes
可作为咪唑用于酸的活化的反应性试剂：酯、酰胺、酮等的合成。用于固定化酶和亲和配体的试剂；近来作为羰基转移试剂用于各种杂环的合成
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Mechanochemical 1, 1′-Carbonyldiimidazole-Mediated Synthesis of Carbamates
Lanzillotto M, et al.
ACS sustainable chemistry & engineering, 11(3), 2882-2889 (2015)
J. Barluenga et al.
The Journal of Organic Chemistry, 56, 6751-6751 (1991)
Activation of cellulose membranes with 1, 1′-carbonyldiimidazole or 1-cyano-4-dimethylaminopyridinium tetrafluoroborate as a basis for the development of immunosensors
Stollner, D, et al.
Analytical Biochemistry, 2(304), 157-165 (2002)
S.K. Kang et al.
Synthetic Communications, 23, 2219-2219 (1993)
1,1'-Carbonyldiimidazole-mediated immobilization of enzymes and affinity ligands.
M T Hearn
Methods in enzymology, 135, 102-117 (1987-01-01)
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