InChI key
DPHCXXYPSYMICK-UHFFFAOYSA-N
InChI
1S/C6H3ClFNO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H
SMILES string
[O-][N+](=O)c1ccc(F)c(Cl)c1
assay
98%
form
solid
mp
40-42 °C (lit.)
Quality Level
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Application
2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:
- benzoimidolones on Ameba resin
- methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate
General description
2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)6 and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
Microwave mediated reduction of heterocycle and fluorine containing nitroaromatics with Mo (CO)6 and DBU.
Spencer J, et al.
Tetrahedron, 64(44), 10195-10200 (2008)
Practical and efficient synthesis of N-fused tricyclic indoles.
Koay N, et al.
Tetrahedron Letters, 52(1), 122-124 (2011)
Microwave-assisted traceless synthesis of benzimidazolones.
Xu X-J and Zong Y-X.
Tetrahedron Letters, 48(1), 129-132 (2007)
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