244929
乙二胺氯化铂(II)
99%, solid
别名:
二氯化乙二胺铂, 二氯（1,2-乙二胺）铂, 二氯（1,2-二氨基乙烷）铂
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关于此项目
线性分子式:
(H2NCH2CH2NH2)PtCl2
化学文摘社编号:
分子量:
326.08
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12161600
EC Number:
237-943-4
MDL number:
产品名称
乙二胺氯化铂(II), 99%
InChI key
LMABILRJNNFCPG-UHFFFAOYSA-L
InChI
1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2
SMILES string
Cl[Pt]Cl.NCCN
assay
99%
form
solid
reaction suitability
core: platinum
reagent type: catalyst
Quality Level
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
S Isonishi et al.
British journal of cancer, 69(2), 217-221 (1994-02-01)
Sensitivity to platinum-containing drugs is believed to be a function of how much drug enters the cell, the extent of DNA adduct formation and the rate at which DNA is repaired. Activation of protein kinase C by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was
R J Holmes et al.
Journal of inorganic biochemistry, 85(2-3), 209-217 (2001-06-19)
A series of intercalator-tethered platinum(II) complexes PtLCl(2) have been prepared where L are the diamine ligands N-[2-[(aminoethyl)amino]ethyl]-9-aminoacridine-4-carboxamide, N-[3-[(2-aminoethyl)amino]propyl]-9-aminoacridine-4-carboxamide, N-[4-[(2-aminoethyl)amino]butyl]-9-aminoacridine-4-carboxamide and N-[5-[(aminoethyl)amino]pentyl]-9-aminoacridine-4-carboxamide and N-[6-[(aminoethyl)amino]hexyl]-9-aminoacridine-4-carboxamide. The activity of the complexes was assessed in the CH-1, CH-1cisR, 41M, 41McisR and SKOV-3 cell lines.
L C Perrin et al.
Anti-cancer drug design, 14(3), 243-252 (1999-09-29)
An in vitro transcription assay was used to probe the sequence specificity of the binding of phenazine-tethered platinum complexes to DNA. It was found that when compared to cis-dichloro(ethylenediamine)platinum(II), the number of RNA polymerase blockage sites was increased by approximately
V Murray et al.
Biochemistry, 31(47), 11812-11817 (1992-12-01)
The sequence specificity of DNA damage caused by cis-diamminedichloroplatinum(II) (cisplatin) and four analogues in human (HeLa) cells was studied using Taq DNA polymerase and a linear amplification system. The primer extension is inhibited by the drug-DNA adducts, and hence the
R Jamshidipour et al.
Cancer chemotherapy and pharmacology, 34(6), 484-490 (1994-01-01)
Cholecystokinin (CCK) is an important trophic hormone for the pancreas, and CCK receptors are present on pancreatic carcinoma cells. We sought to determine whether either CCK itself or an antagonist of CCK could modulate the sensitivity of the human pancreatic
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