244929
乙二胺氯化铂(II)
99%, solid
别名:
二氯化乙二胺铂, 二氯（1,2-乙二胺）铂, 二氯（1,2-二氨基乙烷）铂
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关于此项目
线性分子式:
(H2NCH2CH2NH2)PtCl2
化学文摘社编号:
分子量:
326.08
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12161600
EC Number:
237-943-4
MDL number:
产品名称
乙二胺氯化铂(II), 99%
InChI key
LMABILRJNNFCPG-UHFFFAOYSA-L
InChI
1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2
SMILES string
Cl[Pt]Cl.NCCN
assay
99%
form
solid
reaction suitability
core: platinum, reagent type: catalyst
Quality Level
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
E Kimura et al.
Cancer chemotherapy and pharmacology, 32(6), 419-424 (1993-01-01)
Expression of the heat-shock protein HSP-60 is associated with poor survival in patients with ovarian carcinoma. We examined both the nature of the interaction between hyperthermia and cisplatin (DDP) using the human ovarian carcinoma cell line 2008 and the effect
T J Kelley et al.
Cancer biochemistry biophysics, 13(3), 135-146 (1993-06-01)
Cisplatin (cis-diamminedichloroplatinum(II); cis-DDP) is used as an effective drug for treatment of a variety of cancers, such as carcinomas of bladder, ovarian, and testicular origin. Immunopurified DNA polymerase-alpha from rat prostate tumor PA-3 cells was inhibited (50%) in the presence
B E Bowler et al.
Biochemistry, 25(10), 3031-3038 (1986-05-20)
We report the DNA binding site preferences of the novel molecule AO-Pt, in which the anticancer drug dichloro(ethylenediamine)platinum(II) is linked by a hexamethylene chain to acridine orange. The sequence specificity of platinum binding was mapped by exonuclease III digestion of
W L Armarego et al.
European journal of biochemistry, 164(2), 403-409 (1987-04-15)
Potassium tetrachloroplatinate (K2PtCl4) inactivates dihydropteridine reductase from human brain in a time-dependent and irreversible manner. The inactivation has been followed by measuring enzyme activity and fluorescence changes. The enzyme is completely protected from inactivation by NADH, the pterin cofactor [quinonoid
T W Hambley et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 6(5-6), 534-542 (2001-07-27)
The rate and extent of binding of [PtCl2(hpip)] (hpip=homopiperazine-1,4-diazacycloheptane) and cis-[PtCl2(NH3)2] to calf thymus DNA was measured using atomic absorption spectroscopy and it was found that [PtCl2(hpip)] bound both more rapidly and to a greater extent than did cis-[PtCl2(NH3)2]. The
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