287334
曲安奈德
别名:
9α-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Fluoxyprednisolone
旋光性
[α]25/D +69°, c = 2 in DMF
mp
262-263 °C (lit.)
SMILES字符串
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C
InChI
1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
InChI key
GFNANZIMVAIWHM-OBYCQNJPSA-N
基因信息
human ... NR3C1(2908)
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生化/生理作用
Triamcinolone is a synthetic glucocorticoid agonist; induces gene expression and apoptosis; inhibits prostaglandin synthesis; impairs tumor necrosis factor (TNF)-α-induced degradation of κB-α; potentiates the differentiation-inducing effects of bone morphogenetic proteins (BMP-2, -4, -6).
Justis P Ehlers et al.
The British journal of ophthalmology, 97(11), 1384-1386 (2013-04-25)
Optical coherence tomography (OCT) has revolutionised clinical ophthalmology. The translation of OCT into the operating room is a natural next step given its high-resolution anatomic information. Contrast agents and enhancement have significantly improved the diagnostic capabilities of numerous imaging modalities
Wai-Leung Langston Suen et al.
Journal of controlled release : official journal of the Controlled Release Society, 167(1), 21-28 (2013-01-15)
We are proposing folate-decorated polymeric nanoparticles as carriers of poorly soluble drug molecules for intracellular and prolonged delivery to retinal pigment epithelium (RPE) cells. RPE is a monolayer of epithelial cells that forms the outer blood-retinal barrier in the posterior
Thøger Persson Krogh et al.
The American journal of sports medicine, 41(3), 625-635 (2013-01-19)
Lateral epicondylitis (LE) is a common musculoskeletal disorder for which an effective treatment strategy remains unknown. To examine whether a single injection of platelet-rich plasma (PRP) is more effective than placebo (saline) or glucocorticoid in reducing pain in adults with
Andrew Y H Chin et al.
The Journal of hand surgery, 38(2), 316-321 (2013-01-09)
We report a series of 18 patients with chronic sesamoiditis of the metacarpophalangeal joint of the thumb treated in the period from 1997 to 2002. We describe a diagnostic clinical test (sesamoid provocation test [SPT]) and present the long-term results
Mariana Figueiroa Careta et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(5), 734-738 (2013-02-06)
Earlobe keloids are benign, fibrous proliferations that occur in predisposed persons at sites of cutaneous injury. No single best therapeutic modality is indicated. To describe a 1-year follow-up of 12 patients with earlobe keloids treated by shaving followed by cryosurgery
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