287334
曲安奈德
别名:
9α-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Fluoxyprednisolone
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关于此项目
经验公式（希尔记法）:
C21H27FO6
化学文摘社编号:
分子量:
394.43
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
204-718-7
MDL number:
InChI key
GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI
1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
SMILES string
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C
optical activity
[α]25/D +69°, c = 2 in DMF
mp
262-263 °C (lit.)
Gene Information
human ... NR3C1(2908)
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Biochem/physiol Actions
Triamcinolone is a synthetic glucocorticoid agonist; induces gene expression and apoptosis; inhibits prostaglandin synthesis; impairs tumor necrosis factor (TNF)-α-induced degradation of κB-α; potentiates the differentiation-inducing effects of bone morphogenetic proteins (BMP-2, -4, -6).
Neil A Manson et al.
Canadian journal of surgery. Journal canadien de chirurgie, 56(2), 89-96 (2013-01-29)
The median orthopedic surgery wait time in Canada is 33.7 weeks, thus alternative treatments for pathologies such as lumbar disc herniations (LDH) are needed. We sought to determine whether transforaminal epidural steroid injections (TFESIs) alleviate or merely delay the need
Toine F H Bovee et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(2), 264-271 (2012-11-29)
Use of hormones for fattening purposes is forbidden in the animal production in Europe (European Commission. 1996. Council Directive EC/96/22 (replacement of 88/146/EC). Off J Eur Commun. L125:3-9; European Commission. 1996. Council Directive EC/96/23. Off J Eur Commun. L125:10-32). Moreover
Hao Chen et al.
Investigative ophthalmology & visual science, 54(3), 2178-2185 (2013-03-02)
We sought to better characterize the intravitreal profile of different triamcinolone formulations. The study was performed in vitro and in vivo. Kenalog-40, Triesence, and Transton were characterized for ocular pharmacokinetics, particle size, crystallinity, and dissolving kinetics in vitreous following an
Marion R Munk et al.
The British journal of ophthalmology, 97(10), 1289-1296 (2013-08-06)
To evaluate morphological changes due to uveitis-associated cystoid macular oedema (uvCME) and their impact on central retinal sensitivity (CRS) before and after intravitreal triamcinolone-acetonide (IVTA). 28 eyes with uvCME were examined with microperimetry and spectral-domain optical-coherence-tomography (SD-OCT) before and after
Justis P Ehlers et al.
The British journal of ophthalmology, 97(11), 1384-1386 (2013-04-25)
Optical coherence tomography (OCT) has revolutionised clinical ophthalmology. The translation of OCT into the operating room is a natural next step given its high-resolution anatomic information. Contrast agents and enhancement have significantly improved the diagnostic capabilities of numerous imaging modalities
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