287334
曲安奈德
别名:
9α-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Fluoxyprednisolone
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关于此项目
经验公式（希尔记法）:
C21H27FO6
化学文摘社编号:
分子量:
394.43
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
204-718-7
MDL number:
InChI key
GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI
1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
SMILES string
[H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C
optical activity
[α]25/D +69°, c = 2 in DMF
mp
262-263 °C (lit.)
Gene Information
human ... NR3C1(2908)
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Biochem/physiol Actions
Triamcinolone is a synthetic glucocorticoid agonist; induces gene expression and apoptosis; inhibits prostaglandin synthesis; impairs tumor necrosis factor (TNF)-α-induced degradation of κB-α; potentiates the differentiation-inducing effects of bone morphogenetic proteins (BMP-2, -4, -6).
Neil A Manson et al.
Canadian journal of surgery. Journal canadien de chirurgie, 56(2), 89-96 (2013-01-29)
The median orthopedic surgery wait time in Canada is 33.7 weeks, thus alternative treatments for pathologies such as lumbar disc herniations (LDH) are needed. We sought to determine whether transforaminal epidural steroid injections (TFESIs) alleviate or merely delay the need
Toine F H Bovee et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(2), 264-271 (2012-11-29)
Use of hormones for fattening purposes is forbidden in the animal production in Europe (European Commission. 1996. Council Directive EC/96/22 (replacement of 88/146/EC). Off J Eur Commun. L125:3-9; European Commission. 1996. Council Directive EC/96/23. Off J Eur Commun. L125:10-32). Moreover
Justis P Ehlers et al.
The British journal of ophthalmology, 97(11), 1384-1386 (2013-04-25)
Optical coherence tomography (OCT) has revolutionised clinical ophthalmology. The translation of OCT into the operating room is a natural next step given its high-resolution anatomic information. Contrast agents and enhancement have significantly improved the diagnostic capabilities of numerous imaging modalities
Ali Shakir et al.
American journal of physical medicine & rehabilitation, 92(9), 768-775 (2013-02-02)
This study aimed to compare the effectiveness of triamcinolone vs. dexamethasone used in transforaminal epidural steroid injections for the treatment of cervical radiculopathy. This is a retrospective cohort study of patients with cervical radiculopathy who underwent cervical transforaminal epidural steroid
Mariana Figueiroa Careta et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 39(5), 734-738 (2013-02-06)
Earlobe keloids are benign, fibrous proliferations that occur in predisposed persons at sites of cutaneous injury. No single best therapeutic modality is indicated. To describe a 1-year follow-up of 12 patients with earlobe keloids treated by shaving followed by cryosurgery
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