330639
L-丙氨酸甲酯 盐酸盐
99%, for peptide synthesis
别名:
(S)-2-Aminopropionic acid methyl ester hydrochloride, L-Ala-OMe·HCl
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关于此项目
线性分子式:
CH3CH(NH2)COOCH3 · HCl
化学文摘社编号:
分子量:
139.58
NACRES:
NA.22
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
219-652-4
MDL number:
Beilstein/REAXYS Number:
3594033
产品名称
L-丙氨酸甲酯 盐酸盐, 99%
InChI key
IYUKFAFDFHZKPI-DFWYDOINSA-N
InChI
1S/C4H9NO2.ClH/c1-3(5)4(6)7-2;/h3H,5H2,1-2H3;1H/t3-;/m0./s1
SMILES string
Cl.COC(=O)[C@H](C)N
assay
99%
optical activity
[α]25/D +7.0°, c = 1.6 in methanol
reaction suitability
reaction type: solution phase peptide synthesis
mp
109-111 °C (lit.)
application(s)
peptide synthesis
Quality Level
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Application
L-丙氨酸甲酯盐酸盐可作为起始材料用于液相多肽合成法合成丙氨酸异恶唑烷(alanine isoxazolidide)。也用于合成N-Fmoc-l-丙氨酰-l-丙氨酸甲酯和α-氨基酸基树枝化基元(sector block dendrons)。
General description
L-丙氨酸甲酯盐酸盐，又称为L-Ala-OMe·HCl，是一种多功能试剂，常用于液相多肽合成法。常用于合成二肽。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Synthesis and gelation properties of a new class of $\alpha$-amino acid-based sector block dendrons
HF Chow
Tetrahedron, 61, 11279-11290 (2005)
The dimethylsulfoxonium methylide as unique reagent for the simultaneous deprotection of amino and carboxyl function of N-Fmoc-?-amino acid and N-Fmoc-peptide esters
M Spinella
Tetrahedron, 69, 2010-2016 (2013)
Hala Bakr El-Nassan et al.
Pharmaceutical research, 35(8), 149-149 (2018-05-31)
To assess the gelation power of N-palmitoyl L-alanine derivatives in injectable oils and to use the best chosen organogel as parenteral implant of granisetron for the treatment of emesis. Twelve N-palmitoyl L-alanine derived organogels were developed and evaluated in terms
Jingwen Luo et al.
Drug development and industrial pharmacy, 45(1), 96-104 (2018-09-11)
This article aims to design low molecular weight chitosan (LMWC)-based conjugates of Rhein (RH) by means of an amino acid linker (Alanine) for improved solubility and enhanced bioavailability. Rhein is a potential candidate for the therapy of kidney disease. However
N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase
ML Di Gioia
The Journal of Organic Chemistry, 70, 3892-3897 (2005)
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