338257
异丁基溴化镁 溶液
2.0 M in diethyl ether
别名:
iBuMgBr solution
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关于此项目
线性分子式:
(CH3)2CHCH2MgBr
化学文摘社编号:
分子量:
161.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
Concentration:
2.0 M in diethyl ether
Form:
liquid
InChI
1S/C4H9.BrH.Mg/c1-4(2)3;;/h4H,1H2,2-3H3;1H;/q;;+1/p-1
SMILES string
CC(C)C[Mg]Br
InChI key
CMWBEISSZHZIMU-UHFFFAOYSA-M
form
liquid
reaction suitability
reaction type: Grignard Reaction
concentration
2.0 M in diethyl ether
density
0.941 g/mL at 25 °C
Quality Level
Application
Isobutylmagnesium bromide (iBuMgBr) is a general Grignard reagent used in the total synthesis of (+)-rishirilide B, glucolipsin A, and (+)-juvabione. It can also be used as a reagent in the synthesis of pyrrolidine-based influenza neuraminidase (NA) inhibitors.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
存储类别
4.3 - Hazardous materials which set free flammable gases upon contact with water
wgk
WGK 3
flash_point_f
-29.2 °F - closed cup
flash_point_c
-34 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves
法规信息
危险化学品
易制毒化学品（2类）
此项目有
Structure assignment, total synthesis, and evaluation of the phosphatase modulating activity of glucolipsin A.
Furstner A, et al.
The Journal of Organic Chemistry, 69(2), 459-467 (2004)
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Maring CJ, et al.
Journal of Medicinal Chemistry, 48(12), 3980-3990 (2005)
Total synthesis of (+)-rishirilide B: Development and application of general processes for enantioselective oxidative dearomatization of resorcinol derivatives.
Mejorado LH and Pettus TRR
Journal of the American Chemical Society, 128(49), 15625-15631 (2006)
Enantio-and diastereocontrolled synthesis of (+)-juvabione employing organocatalytic desymmetrisation and photoinduced fragmentation.
Itagaki N and Iwabuchi Y
Chemical Communications (Cambridge, England), 69(11), 1175-1176 (2007)
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