2-氟-5-硝基苯甲酸

Name: 2-氟-5-硝基苯甲酸
Brand: ALDRICH

98%

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About This Item

线性分子式:

FC₆H₃(NO₂)CO₂H

CAS Number:

7304-32-7

分子量:

185.11

MDL编号:

MFCD00134238

UNSPSC代码:

12352100

PubChem化学物质编号:

24862326

NACRES:

NA.22

质量水平

100

方案

98%

表单

solid

mp

142-144 °C (lit.)

官能团

carboxylic acid
fluoro
nitro

SMILES字符串

OC(=O)c1cc(ccc1F)[N+]([O-])=O

InChI

1S/C7H4FNO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11)

InChI key

ICXSHFWYCHJILC-UHFFFAOYSA-N

一般描述

2-Fluoro-5-nitrobenzoic acid is reported to react with an aldehyde, isonitrile and a primary amine tethered to a Boc-protected internal amino or hydroxyl nucleophile, to afford the Ugi product.

应用

2-Fluoro-5-nitrobenzoic acid may be used in the synthesis of:

dibenz[b,f]oxazepin-11(10H)-ones, via the nucleophilic aromatic substitution (S_NAr) of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH of various 2-aminophenols on solid support
synthesis of substituted dibenzazocines on solid support, via S_NAr of fluorine in 2-fluoro-5-nitrobenzoic acid with the OH function of the immobilized polysubstituted phenols
in the synthesis of oxazepines