379115
N,N′-二环己基碳二亚胺 溶液
1.0 M in methylene chloride, for peptide synthesis
别名:
DCC
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关于此项目
线性分子式:
C6H11N=C=NC6H11
化学文摘社编号:
分子量:
206.33
UNSPSC Code:
12352111
PubChem Substance ID:
NACRES:
NA.22
MDL number:
产品名称
N,N′-二环己基碳二亚胺 溶液, 1.0 M in methylene chloride
SMILES string
C1CCC(CC1)N=C=NC2CCCCC2
InChI
1S/C13H22N2/c1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13/h12-13H,1-10H2
InChI key
QOSSAOTZNIDXMA-UHFFFAOYSA-N
form
liquid
Quality Level
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
reaction suitability
reaction type: Coupling Reactions
concentration
1.0 M in methylene chloride
density
1.247 g/mL at 25 °C
application(s)
peptide synthesis
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Application
DCC（ N ， N ′）-二环己基碳二亚胺）主要用于介导肽偶联 ，也可活化羧酸进行酯化。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Liposomes containing alkylated methotrexate analogues for phospholipase A 2 mediated tumor targeted drug delivery.
Kaasgaard T, et al.
Chemistry and Physics of Lipids, 157(2), 94-103 (2009)
Effects of amounts of additives on peptide coupling mediated by a water?soluble carbodiimide in alcohols.
Nozaki S.
The Journal of Peptide Research, 54(2), 162-167 (1999)
Masashi Toei et al.
The Journal of biological chemistry, 288(36), 25717-25726 (2013-07-31)
N,N-Dicyclohexylcarbodiimide (DCCD) is a classical inhibitor of the F0F1-ATP synthase (F0F1), which covalently binds to the highly conserved carboxylic acid of the proteolipid subunit (c subunit) in F0. Although it is well known that DCCD modification of the c subunit
Denys Pogoryelov et al.
Nature chemical biology, 6(12), 891-899 (2010-10-26)
The microscopic mechanism of coupled c-ring rotation and ion translocation in F(1)F(o)-ATP synthases is unknown. Here we present conclusive evidence supporting the notion that the ability of c-rings to rotate within the F(o) complex derives from the interplay between the
Kenji Mizutani et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13474-13479 (2011-08-05)
The prokaryotic V-ATPase of Enterococcus hirae, closely related to the eukaryotic enzymes, provides a unique opportunity to study the ion-translocation mechanism because it transports Na(+), which can be detected by radioisotope (22Na(+)) experiments and X-ray crystallography. In this study, we
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