41996
N-羟基-7-偶氮苯并三氮唑 溶液
~0.6 M in DMF, for peptide synthesis
别名:
3H-[1,2,3]-三唑[4,5-b]吡啶-3-醇, HOAt
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关于此项目
经验公式（希尔记法）:
C5H4N4O
化学文摘社编号:
分子量:
136.11
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
Beilstein/REAXYS Number:
1211115
产品名称
N-羟基-7-偶氮苯并三氮唑 溶液, ~0.6 M in DMF
InChI key
FPIRBHDGWMWJEP-UHFFFAOYSA-N
SMILES string
On1nnc2cccnc12
InChI
1S/C5H4N4O/c10-9-5-4(7-8-9)2-1-3-6-5/h1-3,10H
form
liquid
reaction suitability
reaction type: Addition Reactions
concentration
~0.6 M in DMF
impurities
<1.0% water
refractive index
n20/D 1.441
density
0.978 g/mL at 20 °C
application(s)
peptide synthesis
Quality Level
General description
1-羟基-7-氮杂苯并三唑溶液，又称3H-[1,2,3]-三唑并[4,5-b]吡啶-3-醇，是一种苯并三唑类添加剂，常用作氨基酸和肽的偶联试剂。它还被用于最小化对映异构体生成。
Application
1-羟基-7-氮杂苯并三唑溶液被用作手性肽核酸的固相合成试剂。
Other Notes
偶联添加剂，用于肽合成中的高效无外消旋偶联； 片段偶联。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
136.4 °F - closed cup
flash_point_c
58 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Y. Nishiyama et al.
Tetrahedron Letters, 42, 8789-8789 (2001)
L.A. Carpino et al.
The Journal of Organic Chemistry, 60, 3561-3561 (1995)
{Synthetic Studies towards the Calcium-Dependent Lipopeptide Antibiotic Cadaside B
Nadiia K,et al.
Chemistry?A European Journal , 28, e202202554-e202202554 (2022)
Oxyma-B, an excellent racemization suppressor for peptide synthesis
Yahya JE,et al.
Organic & Biomolecular Chemistry, 12, 8379-8385 (2014)
Júlia García-Pindado et al.
Biopolymers, 109(10), e23112-e23112 (2018-03-13)
While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated
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