460923
炔丙基氯甲酸酯
96%
别名:
(丙炔-2-氧基)碳酰氯, 2-丙炔-1-基氯甲酸丙酯, 丙炔氧羰酰氯, 氯甲酸 2-丙炔酯
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关于此项目
线性分子式:
HC≡CCH2OCOCl
化学文摘社编号:
分子量:
118.52
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
1745399
Assay:
96%
InChI
1S/C4H3ClO2/c1-2-3-7-4(5)6/h1H,3H2
SMILES string
ClC(=O)OCC#C
InChI key
RAMTXCRMKBFPRG-UHFFFAOYSA-N
vapor pressure
0.65 psi ( 20 °C)
assay
96%
reaction suitability
reaction type: click chemistry
Quality Level
bp
118-122 °C (lit.)
density
1.215 g/mL at 25 °C (lit.)
functional group
chloro
storage temp.
2-8°C
General description
氯甲酸炔丙酯是一种炔丙基酯。它是羟基和氨基的保护基团。本文用扩展的 Grunwald-Winstein 方程分析了氯甲酸炔丙酯在各种不同亲核能力和电离功率的溶剂中的溶剂分解速率。
Application
氯甲酸炔丙酯可用于制备以下物质：
- 联萘酚二乙炔衍生物
- 丙炔五氟苯基碳酸酯
- N -Poc 保护的氨基酸（Poc = 炔丙基氧羰基）
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
86.0 °F - closed cup
flash_point_c
30 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Synthesis and applications of propargyl pentafluorophenyl carbonate for peptide synthesis.
Bhat RG, et al.
Tetrahedron Letters, 43(13), 2467-2469 (2002)
Malcolm J D'Souza et al.
ISRN organic chemistry, 2011 (2011-06-15)
The specific rates of solvolysis of propargyl chloroformate (1) are analyzed in 22 solvents of widely varying nucleophilicity and ionizing power values at 25.0 °C using the extended Grunwald-Winstein equation. Sensitivities to solvent nucleophilicity (l) of 1.37 and to solvent
Propargyloxycarbonyl (Poc) amino acid chlorides as efficient coupling reagents for the synthesis of 100% diastereopure peptides and resin bound tetrathiomolybdate as an effective deblocking agent for the Poc group.
Bhat RG, et al.
Chemical Communications (Cambridge, England), 8, 812-813 (2002)
Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions.
Fukase Y, et al.
Tetrahedron Letters, 40(6), 1169-1170 (1999)
Organogold (I) complexes of a C 2-symmetric diacetylide ligand derived from 1, 1'-bi-2-naphthol.
Burchell TJ, et al.
Inorgorganica Chimica Acta, 359(9), 2812-2818 (2006)
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