472611
(1,3-二氧戊环-2-基甲基)溴化镁 溶液
0.5 M in THF
别名:
2-[(Bromomagnesio)methyl]-1,3-dioxolane, Bromo(1,3-dioxolan-2-ylmethyl)magnesium
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关于此项目
经验公式（希尔记法）:
C4H7BrMgO2
化学文摘社编号:
分子量:
191.31
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352103
MDL number:
reaction suitability
reaction type: Grignard Reaction
Quality Level
packaging
Sure/Seal™ of
concentration
0.5 M in THF
bp
65-67 °C
density
0.938 g/mL at 25 °C
functional group
ether
SMILES string
Br[Mg]CC1OCCO1
InChI
1S/C4H7O2.BrH.Mg/c1-4-5-2-3-6-4;;/h4H,1-3H2;1H;/q;;+1/p-1
InChI key
ZDNTZRAFJZERSL-UHFFFAOYSA-M
Application
（1,3-二氧戊环-2-基甲基）溴化镁是一种格氏试剂，可用于制备：
- 3-[11C]-丙醛，一种用于合成放射标记化合物[11C]SN-38的关键中间体，其中SN-38代表7-乙基-10-羟基喜树碱。
- 通过与D-甘油醛反应制备1-[(S)-2,2-二甲基-(1,3)-二氧戊环-4-基]-4-(1,3-二氧戊环2-基)-2-醇，其可进一步被用于合成不饱和核苷。
- 一种双环羧酸盐中间体，可用于spirovibsanin A的全合成。
Legal Information
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
target_organs
Central nervous system, Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
1.4 °F - closed cup
flash_point_c
-17 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Synthesis, Structure- Activity Relationships, and Drug Resistance of beta-d-3′-Fluoro-2′, 3′-Unsaturated Nucleosides as Anti-HIV Agents
Zhou W, et al.
Journal of Medicinal Chemistry, 47(13), 3399-3408 (2004)
Towards the Total Synthesis of Spirovibsanin A: Total Synthesis of (pm)-5, 14-Bis-epi-spirovibsanin A
Gallen MJ and Williams CM
European Journal of Organic Chemistry, 2008(27), 4697-4705 (2008)
Synthesis and biodistribution of [11C] SN-38
Apana SM, et al.
Journal of Labelled Compounds & Radiopharmaceuticals, 53(4), 178-182 (2010)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 472611-1L | 04061837902963 |
| 472611-100ML | 04061832360676 |