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Merck
CN

47618

Fmoc-L-天冬氨酸4-叔丁酯

≥98.0% (HPLC), for peptide synthesis

别名:

Fmoc-L-天冬氨酸 4-叔丁酯

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关于此项目

经验公式(希尔记法):
C23H25NO6
化学文摘社编号:
分子量:
411.45
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
276-251-7
MDL number:
Beilstein/REAXYS Number:
3635671
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产品名称

Fmoc-L-天冬氨酸4-叔丁酯, ≥98.0% (HPLC)

Quality Level

assay

≥98.0% (HPLC)

form

powder

optical activity

[α]20/D −24±2°, c = 1% in DMF

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

mp

148-150 °C (dec.)

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

CC(C)(C)OC(=O)C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O

InChI

1S/C23H25NO6/c1-23(2,3)30-20(25)12-19(21(26)27)24-22(28)29-13-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,24,28)(H,26,27)/t19-/m0/s1

InChI key

FODJWPHPWBKDON-IBGZPJMESA-N

General description

Fmoc-Asp(OtBu)-OH又称为Fmoc-L-天冬氨酸4-叔丁酯,在固相多肽合成中用作Fmoc-氨基酸类保护基团。

Application

Fmoc-Asp(OtBu)-OH可用于在Fmoc肽固相合成中防止天冬氨酰亚胺副产物的形成。


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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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New t-butyl based aspartate protecting groups preventing aspartimide formation in Fmoc SPPS
R Behrendt, et.al.
Journal of Peptide Science, 21, 680-687 (2015)
Fengyang Xu et al.
ACS applied materials & interfaces, 8(44), 29906-29914 (2016-10-21)
In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water
Jisi Zhao et al.
Molecules (Basel, Switzerland), 24(4) (2019-03-03)
Photodynamic therapy (PDT) is an established therapeutic modality for the management of cancers. Conjugation with tumor-specific small molecule ligands (e.g., short peptides or peptidomimetics) could increase the tumor targeting of PDT agents, which is very important for improving the outcome



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