Merck
CN
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文件

安全信息

482609

Sigma-Aldrich

N-[(2S,3R)-3-氨基-2-羟基-4-苯基丁酰基]-L-亮氨酸

97%

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别名:
([2S,3R]-3-氨基-2-羟基-4-苯基丁酰基)-L-亮氨酸
线性分子式:
(CH3)2CHCH2CH[NHCOCH(OH)CH(NH2)CH2C6H5]CO2H
CAS号:
58970-76-6
分子量:
308.37
EC 号:
261-529-2
MDL编号:
MFCD00083262
PubChem化学物质编号:
24871835
NACRES:
NA.22

质量水平

100

检测方案

97%

形式

powder or crystals

旋光性

[α]20/D −11°, c = 1 in 1 M NaOH

反应适用性

reaction type: solution phase peptide synthesis

mp

245 °C (dec.) (lit.)

应用

peptide synthesis

SMILES字符串

CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O

InChI

1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1

InChI key

VGGGPCQERPFHOB-RDBSUJKOSA-N

基因信息

human ... ANPEP(290) , DPP4(1803)
mouse ... Rnpep(215615)
rat ... Mme(24590)

相关类别

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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M Lis et al.
Polish journal of veterinary sciences, 14(3), 393-403 (2011-10-01)
Bestatin, a low-molecular weight dipeptide, is a potent inhibitor of aminopeptidase N which has been demonstrated to have antitumor and immunomodulatory effects. The effects of bestatin (10, 1 and 0.1 mg/kg) administered intraperitoneally once, five or ten times to mice
Ines Martin-Padura et al.
Laboratory investigation; a journal of technical methods and pathology, 92(7), 952-966 (2012-05-02)
Hepatocellular carcinoma (HCC) is the fifth most common solid tumor and the third leading cause of cancer-related deaths. Currently available chemotherapeutic options are not curative due in part to tumor resistance to conventional therapies. We generated orthotopic HCC mouse models
Ching-Feng Huang et al.
International archives of allergy and immunology, 158(2), 142-150 (2012-01-31)
DNA vaccines encoding allergens have been developed to prevent or to treat specific IgE responses. To evaluate the potential preventive and therapeutic effect of DNA vaccines encoding Cyn d 1 alone or combined with different adjuvants on specific allergies. Recombinant
Kunio Fujiwara et al.
Journal of molecular histology, 42(6), 589-596 (2011-10-19)
The in vivo role of transporters in drug disposition, in the context of other transporters, and metabolism has not been established. We prepared an anti-bestatin serum against bestatin conjugated to albumin with glutaraldehyde (GA). The antiserum was specific for GA-conjugated
Magdalena Lis et al.
Pharmacological reports : PR, 63(6), 1481-1490 (2012-02-24)
The low-molecular weight dipeptide bestatin is a potent inhibitor of aminopeptidase N and has been demonstrated to have antitumor and immunomodulatory effects. The effects of bestatin on interleukin (IL)-1β synthesis and release by peritoneal macrophages stimulated in vitro with lipopolysaccharide
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