512443
3-氯-L-酪氨酸
97%
别名:
(2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid, Monochlorotyrosine
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关于此项目
线性分子式:
4-(HO)C6H3(Cl)CH2CH(NH2)CO2H
化学文摘社编号:
分子量:
215.63
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
NACRES:
NA.22
EC Number:
231-050-3
MDL number:
InChI key
ACWBBAGYTKWBCD-ZETCQYMHSA-N
InChI
1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1
SMILES string
N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O
assay
97%
optical activity
[α]24/D −2°, c = 1 in 1 M HCl
reaction suitability
reaction type: solution phase peptide synthesis
mp
249 °C (lit.)
application(s)
peptide synthesis
Quality Level
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jihan Talib et al.
Free radical biology & medicine, 53(1), 20-29 (2012-05-23)
Smokers have an elevated risk of atherosclerosis but the origin of this elevated risk is incompletely defined, though increasing evidence supports a role for the oxidant-generating enzyme myeloperoxidase (MPO). In previous studies we have demonstrated that smokers have elevated levels
Mariusz G Fleszar et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-11)
Quantification with satisfactory specificity and sensitivity of free 3-Nitro-l-tyrosine (3-NT), 3-Chloro-l-tyrosine (3-CT), and 3-Bromo-l-tyrosine (3-BT) in biological samples as potential inflammation, oxidative stress, and cancer biomarkers is analytically challenging. We aimed at developing a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method
Cédric Delporte et al.
Talanta, 99, 603-609 (2012-09-13)
A high degree of uremia is common in patients with end-stage renal disease and has been linked to the development of chronic inflammation and cardiovascular diseases. In conditions where transplantation is not possible, uremia can be reduced by hemodialysis although
Joseph I Kang et al.
Chemical research in toxicology, 21(5), 1028-1038 (2008-05-03)
While the last 30 years chronicles an extensive effort to understand the damage to DNA caused by reactive oxygen species (ROS), little research has examined the chemical damage to the histone proteins found in chromatin. Hypochlorous acid (HOCl), the primary
Mei-Ling Cheng et al.
Clinical biochemistry, 41(7-8), 554-560 (2008-03-04)
Inflammation, a major risk factor for acute myocardial infarction (AMI), is associated with leukocytic activation, secretion of myeloperoxidase (MPO) and generation of the oxidative damage marker, 3-chlorotyrosine (3-Cl-Tyr). To study their association with AMI and their value in diagnosis of
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