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文件

535087

2-氟腺嘌呤

Name: 2-氟腺嘌呤
Brand: ALDRICH

96%

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所有图片(1)

别名:

2-氟-6-氨基嘌呤

经验公式（希尔记法）:

C₅H₄FN₅

CAS号:

700-49-2

分子量:

153.12

MDL编号:

MFCD01632749

PubChem化学物质编号:

24878071

NACRES:

NA.22

质量水平

100

检测方案

96%

mp

>350 °C (lit.)

SMILES字符串

Nc1[nH]c(F)nc2ncnc12

InChI

1S/C5H4FN5/c6-5-10-3(7)2-4(11-5)9-1-8-2/h1H,(H3,7,8,9,10,11)

InChI key

WKMPTBDYDNUJLF-UHFFFAOYSA-N

象形图

GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine.

Sepideh Afshar et al.

Protein science : a publication of the Protein Society, 18(5), 1107-1114 (2009-04-24)

A double mutant of human purine nucleoside phosphorylase (hDM) with the amino acid mutations Glu201Gln:Asn243Asp cleaves adenosine-based prodrugs to their corresponding cytotoxic drugs. When fused to an anti-tumor targeting component, hDM is targeted to tumor cells, where it effectively catalyzes

Comparison of gene targeting efficiencies in two mosses suggests that it is a conserved feature of Bryophyte transformation.

Bénédicte Trouiller et al.

Biotechnology letters, 29(10), 1591-1598 (2007-06-15)

The moss, Physcomitrella patens, is a novel tool in plant functional genomics due to its exceptionally high gene targeting efficiency that is so far unique for plants. To determine if this high gene targeting efficiency is exclusive to P. patens

Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus.

X Y Wang et al.

Gene therapy, 11(21), 1559-1567 (2004-09-03)

Gene-directed enzyme prodrug therapy (GDEPT) based on the Escherichia coli enzyme, purine nucleoside phosphorylase (PNP), provides a novel strategy for treating slowly growing tumors like prostate cancer (CaP). PNP converts systemically administered prodrug, fludarabine phosphate, to a toxic metabolite, 2-fluoroadenine

Metabolic cooperation between mouse mammary tumor subpopulations in three-dimensional collagen gel cultures.

B E Miller et al.

Cancer research, 46(1), 89-93 (1986-01-01)

A series of subpopulation lines derived from a single mouse mammary tumor were tested for their ability to interact with each other in metabolic cooperation assays in three-dimensional collagen gel cultures. Inhibition of growth in the presence of selective drug

Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models.

D Voeks et al.

Gene therapy, 9(12), 759-768 (2002-06-01)

A gene-directed enzyme pro-drug therapy (GDEPT) based on purine nucleoside phosphorylase (PNP), that converts the prodrug, fludarabine to 2-fluoroadenine, has been described, but studies are limited compared with other GDEPTs. We investigated the in vitro and in vivo efficacies of

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