Quality Level
assay
97%
form
solid
mp
37-41 °C (lit.)
functional group
chloro, fluoro
SMILES string
Fc1cnc(Cl)nc1Cl
InChI
1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChI key
WHPFEQUEHBULBW-UHFFFAOYSA-N
Application
2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:
- 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
- A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
- 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
- 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
- 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
- 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
222.8 °F - closed cup
flash_point_c
106 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Practical synthesis of 5-fluoro-2-(piperidin-4-yloxy) pyrimidin-4-amine, a key intermediate in the preparation of potent deoxycytidine kinase inhibitors
Zhang H, et al.
Organic Process Research & Development, 13(4), 807-811 (2009)
Design, synthesis, and biological evaluation of a series of novel AXL kinase inhibitors
Mollard A, et al.
ACS Medicinal Chemistry Letters, 2(12), 907-912 (2011)
Optimization of 2, 4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability
Kunikawa S, et al.
Bioorganic & Medicinal Chemistry, 23(13), 3269-3277 (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 653233-1G | 04061825755830 |