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About This Item
经验公式（希尔记法）:
C4HCl2FN2
CAS Number:
分子量:
166.97
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
97%
表单
solid
mp
37-41 °C (lit.)
官能团
chloro
fluoro
SMILES字符串
Fc1cnc(Cl)nc1Cl
InChI
1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChI key
WHPFEQUEHBULBW-UHFFFAOYSA-N
应用
2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:
- 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
- A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
- 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
- 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
- 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
- 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1A
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 3
闪点(°F)
222.8 °F - closed cup
闪点(°C)
106 °C - closed cup
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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