77386
2-溴-1-乙基吡啶四氟硼酸盐
≥97.0% (T)
别名:
BEP
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关于此项目
经验公式（希尔记法）:
C7H9BBrF4N
化学文摘社编号:
分子量:
273.86
Beilstein:
4059265
EC 号:
MDL编号:
UNSPSC代码:
12352005
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
≥97.0% (T)
表单
crystals
反应适用性
reaction type: Coupling Reactions
mp
103-107 °C
应用
peptide synthesis
官能团
bromo
SMILES字符串
F[B-](F)(F)F.CC[n+]1ccccc1Br
InChI
1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8;2-1(3,4)5/h3-6H,2H2,1H3;/q+1;-1
InChI key
YJDXVQLBIAJTHP-UHFFFAOYSA-N
一般描述
2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2?bromo pyridine.
应用
2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:
- The synthesis of N-methylated peptides in solution and solid phase.
- The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.
其他说明
用于肽合成的偶联试剂；与其他试剂如 BOP、PyBrOP、PyClU、BTFFH、CMBI 相比，外消旋作用更低、反应更快
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
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Li P and Xu J
Tetrahedron, 56(41), 8119-8131 (2000)
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The aim of the present study was to demonstrate evidence of reduced thrombin generation at the trough plasma rivaroxaban concentration. A single-centre, prospective, nonrandomized, drug-intervention, self-controlled study was conducted in 51 anticoagulation therapy-naïve patients with nonvalvular atrial fibrillation. Plasma rivaroxaban
2?Bromo?1?ethyl Pyridinium Tetrafluoroborate (BEP)
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2003)
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