808490
N6-炔丙基-ATP 钠盐
别名:
(N6pATP) 钠盐, N6-炔丙基-腺苷-5’-三磷酸盐 钠盐
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关于此项目
经验公式（希尔记法）:
C13H18N5O13P3 · xNa+
分子量:
545.23 (free acid basis)
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.22
SMILES string
O[C@@H]([C@H]1O)[C@@H](COP(O)(OP(O)(OP(O)(O)=O)=O)=O)O[C@@H]1N2C=NC3=C2N=CN=C3NCC#C
InChI
1S/C13H18N5O13P3/c1-2-3-14-11-8-12(16-5-15-11)18(6-17-8)13-10(20)9(19)7(29-13)4-28-33(24,25)31-34(26,27)30-32(21,22)23/h1,5-7,9-10,13,19-20H,3-4H2,(H,24,25)(H,26,27)(H,14,15,16)(H2,21,22,23)/t7-,9-,10-,13?/m1/s1
InChI key
MUOIWXPACQCYQC-RJNFYWFKSA-N
assay
≥95% (HPLC)
form
solid
reaction suitability
reaction type: click chemistry
solubility
10 mM Tris-HCl, pH 7.5: soluble
shipped in
wet ice
storage temp.
−20°C
Quality Level
Application
N6-炔丙基-ATP适用于蛋白质的体外AMPylation以及RNA的体外聚腺苷酸化。可以使用Cu(I)催化的点击化学方法处理所得的炔烃官能化的蛋白质或RNA，以连接叠氮化物标记的分子。这提供了诸如引入用于纯化任务的生物素基团，引入用于检测的荧光基团或与其他叠氮化物官能化的生物分子交联的选择。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Markus Grammel et al.
Journal of the American Chemical Society, 133(43), 17103-17105 (2011-09-29)
Protein AMPylation is an emerging post-translational modification, which plays key roles in bacterial pathogenesis and cell biology. Enzymes with AMPylation activity, referred to as AMPylators, have been identified in several bacterial pathogens and eukaryotes. To facilitate the study of this
A new chemical handle for protein AMPylation at the host-pathogen interface.
Malgorzata Broncel et al.
Chembiochem : a European journal of chemical biology, 13(2), 183-185 (2012-01-04)
Markus Grammel et al.
Chembiochem : a European journal of chemical biology, 13(8), 1112-1115 (2012-04-20)
A versatile "clickable" nucleoside: Metabolic labeling of cells is useful in studying the dynamics of biological molecules. N(6) pA can be utilized by all three mammalian RNA polymerases, as well as poly(A) polymerase. Because of its alkyne modification, RNA labeled
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