900914
Methyltetrazine-NHS ester
≥95%
别名:
2,5-Dioxo-1-pyrrolidinyl 4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetate
质量水平
方案
≥95%
表单
powder or crystals
反应适用性
reaction type: click chemistry
reagent type: cross-linking reagent
官能团
NHS ester
储存温度
−20°C
SMILES字符串
O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3
InChI
1S/C15H13N5O4/c1-9-16-18-15(19-17-9)11-4-2-10(3-5-11)8-14(23)24-20-12(21)6-7-13(20)22/h2-5H,6-8H2,1H3
InChI key
BIHJLZOOHNOUCG-UHFFFAOYSA-N
应用
Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
High-Throughput Chemical Probing of Full-Length Protein?Protein Interactions.
Song J M, et al.
ACS Combinatorial Science, 19(12), 763-769 (2017)
An anti-B cell maturation antigen bispecific antibody for multiple myeloma.
Ramadoss N S, et al.
Journal of the American Chemical Society, 137(16), 5288-5291 (2015)
A click chemistry-based microRNA maturation assay optimized for high-throughput screening.
Lorenz D A and Garner A L
Chemical Communications (Cambridge, England), 52(53), 8267-8270 (2016)
Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.
Henise J, et al.
Bioconjugate Chemistry, 26(2), 270-278 (2015)
商品
Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.
为您的生化或生物共轭研究选择合适的交联剂可能具有挑战性。我们的选择指南可以帮助您找到最适合您应用的交联剂。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持