900914
Methyltetrazine-NHS ester
≥95%
别名:
2,5-Dioxo-1-pyrrolidinyl 4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetate
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H13N5O4
化学文摘社编号:
分子量:
327.29
UNSPSC Code:
12352108
NACRES:
NA.22
MDL number:
Assay:
≥95%
Form:
powder or crystals
InChI
1S/C15H13N5O4/c1-9-16-18-15(19-17-9)11-4-2-10(3-5-11)8-14(23)24-20-12(21)6-7-13(20)22/h2-5H,6-8H2,1H3
InChI key
BIHJLZOOHNOUCG-UHFFFAOYSA-N
SMILES string
O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3
assay
≥95%
form
powder or crystals
Quality Level
reaction suitability
reagent type: cross-linking reagent
functional group
NHS ester
storage temp.
−20°C
Application
Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Song J M, et al.
ACS Combinatorial Science, 19(12), 763-769 (2017)
A click chemistry-based microRNA maturation assay optimized for high-throughput screening.
Lorenz D A and Garner A L
Chemical Communications (Cambridge, England), 52(53), 8267-8270 (2016)
An anti-B cell maturation antigen bispecific antibody for multiple myeloma.
Ramadoss N S, et al.
Journal of the American Chemical Society, 137(16), 5288-5291 (2015)
Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system.
Henise J, et al.
Bioconjugate Chemistry, 26(2), 270-278 (2015)
商品
Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.
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