Methyltetrazine-NHS ester

Name: Methyltetrazine-NHS ester
Brand: ALDRICH

≥95%

别名:

2,5-Dioxo-1-pyrrolidinyl 4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzeneacetate

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所有图片(2)

About This Item

经验公式（希尔记法）:

C₁₅H₁₃N₅O₄

CAS Number:

1644644-96-1

分子量:

327.29

MDL编号:

MFCD28334557

UNSPSC代码:

12352108

NACRES:

NA.22

质量水平

100

方案

≥95%

表单

powder or crystals

反应适用性

reaction type: click chemistry
reagent type: cross-linking reagent

官能团

NHS ester

储存温度

−20°C

SMILES字符串

O=C(ON1C(CCC1=O)=O)CC(C=C2)=CC=C2C3=NN=C(C)N=N3

InChI

1S/C15H13N5O4/c1-9-16-18-15(19-17-9)11-4-2-10(3-5-11)8-14(23)24-20-12(21)6-7-13(20)22/h2-5H,6-8H2,1H3

InChI key

BIHJLZOOHNOUCG-UHFFFAOYSA-N

应用

Methyltetrazine-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and a methyltetrazine, which is reactive to trans-cyclooctenes. The NHS ester reacts with primary amines (e.g. side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic pH to form covalent bonds. The short spacer arm adds minimal mass to modified molecules (230.2 daltons). It is generally used in click chemistry applications in bioconjugate chemistry.