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901487

(S,S,S)-AHPC hydrochloride

≥97%

别名:

(2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand negative control epimer, Ligand for PROTAC® research, VH032 negative control

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关于此项目

经验公式（希尔记法）:
C22H30N4O3S · xHCl
化学文摘社编号:
2115897-23-7
分子量:
430.56 (free base basis)
MDL number:
MFCD32062443
UNSPSC Code:
12352101
NACRES:
NA.22
Assay:
≥97%
Form:
powder or crystals
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ligand

VH032

Quality Level

100

assay

≥97%

form

powder or crystals

reaction suitability

reagent type: ligand

storage temp.

2-8°C

SMILES string

N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@H](O)C1)=O)C(C)(C)C.Cl

InChI

1S/C22H30N4O3S.ClH/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4;/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28);1H/t16-,17-,19+;/m0./s1

InChI key

JYRTWGCWUBURGU-ITJMAPPJSA-N

Application

(S,S,S)-AHPC (HCl salt) is a ligand used as a negative control for (S,R,S)-AHPC (cat# 901490) in the recruitment of the von Hippel–Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Small-Molecule PROTACS: New Approaches to Protein Degradation

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000399303
0000399303
MKCR9864
MKCG6337

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Degrader Building Blocks for Targeted Protein Degradation

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Journal of medicinal chemistry, 61(2), 599-618 (2017-08-31)
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Journal of medicinal chemistry, 61(2), 583-598 (2017-07-12)
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全球贸易项目编号

货号GTIN
901487-10MG-KC04065272217217
901487-10MG04061834671503
901487-100MG04065267009216