902675
BocNH-PEG6-acid
别名:
2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH2COOH
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关于此项目
经验公式（希尔记法）:
C19H37NO10
化学文摘社编号:
分子量:
439.50
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
Form:
liquid
form
liquid
reaction suitability
reagent type: linker
refractive index
n/D 1.4657
functional group
Boc, amine, carboxylic acid
storage temp.
−20°C
SMILES string
OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
InChI
1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)
InChI key
ZKCDWMFMVAYYED-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable