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Merck
CN

920495

2-(6-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazin-2-yl)acetic acid

别名:

Rigid linker for PROTAC® development

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关于此项目

经验公式（希尔记法）:
C14H19N3O4
分子量:
293.32
MDL number:
MFCD34602189
UNSPSC Code:
12352106
NACRES:
NA.22

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InChI

1S/C14H19N3O4/c1-14(2,3)21-13(20)17-7-9(8-17)11-6-15-5-10(16-11)4-12(18)19/h5-6,9H,4,7-8H2,1-3H3,(H,18,19)

InChI key

AIWAVIOLLBXRFG-UHFFFAOYSA-N

SMILES string

CC(C)(OC(N1CC(C2=CN=CC(CC(O)=O)=N2)C1)=O)C

form

powder

reaction suitability

reagent type: linker

functional group

Boc
carboxylic acid

storage temp.

2-8°C

Quality Level

100

相关类别

Application

2-(6-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazin-2-yl)acetic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920487
920576
920584
ADV638390284

Other Notes

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

wgk

WGK 3

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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